PUBLICATIONS
Canady Helios Cold Plasma Induces Non-Thermal (24 °C), Non-Contact Irreversible Electroporation and Selective Tumor Cell Death at Surgical Margins
Published: 2 December 2025
Saravana R. K. Murthy, Taisen Zhuang, Olivia Z. Jones, Yasmine Dakak, Michael Keidar, Aviram Nissan, and Jerome Canady.
COLD PLASMA PUBLICATIONS
Canady Helios Cold Plasma Induces Non-Thermal (24 °C), Non-Contact Irreversible Electroporation and Selective Tumor Cell Death at Surgical Margins
Saravana R. K. Murthy, Taisen Zhuang, Olivia Z. Jones, Yasmine Dakak, Michael Keidar, Aviram Nissan, and Jerome Canady. Residual tumor cells left behind after surgery are a major cause of cancer local recurrence. The Canady Helios Cold Plasma (CHCP) system is a...
The First Cold Atmospheric Plasma Phase I Clinical Trial for the Treatment of Advanced Solid Tumors: A Novel Treatment Arm for Cancer
Jerome Canady, Saravana R. K. Murthy, Taisen Zhuang, Steven Gitelis, Aviram Nissan, Lawan Ly, Olivia Z. Jones, Xiaoqian Cheng, Mohammad Adileh, Alan T. Blank, Matthew W. Colman, Kieth Millikan, Cristina O’Donoghue, Kerstin M. Stenson, Karen Ohara, Gal Schtrechman,...
Canady Cold Helios Plasma Reduces Soft Tissue Sarcoma Viability by Inhibiting Proliferation, Disrupting Cell Cycle, and Inducing Apoptosis: A Preliminary Report
Lawan Ly, Xiaoqian Cheng, Saravana R. K. Murthy, Olivia Z. Jones, Taisen Zhuang, Steven Gitelis, Alan T. Blank, Aviram Nissan, Mohammad Adileh, Matthew Colman, Michael Keidar, Giacomo Basadonna and Jerome Canady Soft tissue sarcomas (STS) are a rare and highly...
The Granger Causal Effects of Canady Helios Cold Plasma on the Inhibition of Breast Cancer Cell Proliferation
Annisa Elbedour, Xiaoqian Cheng, Saravana R. K. Murthy, Taisen Zhuang, Lawan Ly, Olivia Jones, Giacomo Basadonna, Michael Keidar, and Jerome CanadyCold atmospheric plasma (CAP) has become a promising tool for modern medicine. With its recent applications in oncology,...
BCL2A1 regulates Canady Helios Cold Plasma-induced cell death in triple-negative breast cancer
Saravana R. K. Murthy, Xiaoqian Cheng, Taisen Zhuang, Lawan Ly, Olivia Jones, Giacomo Basadonna, Michael Keidar, & Jerome CanadyBreast cancer is the most common cause of cancer death among women worldwide1 and it exhibits diverse molecular features that reflect the...
Canady Helios Cold Plasma Induces Breast Cancer Cell Death by Oxidation of Histone mRNA
by Xiaoqian Cheng, Saravana R. K. Murthy, Taisen Zhuang,Lawan Ly,Olivia Jones, Giacomo Basadonna, Michael Keidar, Yasmine Kanaan and Jerome Canady Breast cancer is the most common cancer among women worldwide. Its molecular receptor marker status and mutational...
The synergistic effect of Canady Helios cold atmospheric plasma and a FOLFIRINOX regimen for the treatment of cholangiocarcinoma in vitro
Olivia Jones, Xiaoqian Cheng, Saravana R. K. Murthy, Lawan Ly, Taisen Zhuang, Giacomo Basadonna Michael Keidar & Jerome Canady Cold atmospheric plasma (CAP) has been extensively studied in various biomedical fields. It is a novel approach to targeted cancer treatment...
Canady Cold Plasma Conversion System Treatment: An Effective Inhibitor of Cell Viability in Breast Cancer Molecular Subtypes
Xiaoqian Cheng, Saravana R. K. Murthy, Taisen Zhuang, Lawan Ly, Olivia Jones, Giacomo Basadonna, Michael Keidar, Yasmine Kanaan, and Jerome CanadyBreast cancer is a heterogenous disease which can be classified into subtypes by the presence or absence of estrogen...
Scientific American Top Ten Emerging Technologies of 2019: Canady Cold Plasma
Mark Peplow PhDWhen a surgeon removes a tumor, some cancer cells may get left behind, threatening to seed another malignant growth. Researchers have just begun the first clinical trial of a new anticancer tool that they hope will kill these stubborn cells: a plasma...
Reduced Blood Loss With Use of Canady Hybrid Plasma Scalpel Compared With Bovie Electrocautery in the Resection of Soft-Tissue Sarcomas
Connor J. Wakefield, BS, Chris Culvern, MS, Matthew W. Colman, MD, Jerome Canady, MD, Steven Gitelis, MD, Alan T. Blank, MD, MSAs medicine continues to seek increasingly improved outcomes, many fields have developed novel and innovative treatments. The field of...
A New Cold Plasma Jet: Performance Evaluation of Cold Plasma, Hybrid Plasma and Argon Plasma Coagulation
Lawan Ly, Sterlyn Jones, Alexey Shashurin, Taisen Zhuang, Warren Rowe III, Xiaoqian Cheng, Shruti Wigh, Tammey Naab, Michael Keidar, and Jerome CanadyElectrosurgery is the use of high frequency radiofrequency (RF) alternating current (AC) for cutting and coagulation...
Treatment of Triple-Negative Breast Cancer Cells with the Canady Cold Plasma Conversion System: Preliminary Results
Xiaoqian Cheng, Warren Rowe, Lawan Ly, Alexey Shashurin, Taisen Zhuang, Shruti Wigh,Giacomo Basadonna, Barry Trink, Michael Keidar, and Jerome CanadyBreast cancer is the most common cancer diagnosed among US women (excluding skin cancers) and is the second leading...
The Canady Helios Cold Plasma Scalpel Significantly Decreases Viability in Malignant Solid Tumor Cells in a Dose-Dependent Manner
Warren Rowe, Xiaoqian Cheng, Lawan Ly, Taisen Zhuang, Giacomo Basadonna, Barry Trink, Michael Keidar, and Jerome Canady Malignant solid tumors are characterized by high recurrence rates and low five-year survival rates. Stage IV renal adenocarcinoma presents an...
Cold Atmospheric Plasma (CAP) Combined with Chemo-Radiation and Cytoreductive Surgery: The First Clinical Experience for Stage IV Metastatic Colon Cancer
J. Canady, M.D., S. Gordon, M.D., T. Zhuang, PhD., S. Wigh, W. Rowe III, PhD., A. Shashurin, PhD., M. Keidar, PhD.Colorectal cancer (CRC) is the third most common cancer in the world and the second leading cause of cancer death in the United States. In 2012 an...
A Novel Micro Cold Atmospheric Plasma Device for Glioblastoma Both In Vitro and In Vivo
Z.Chen, H. Simonyan, X. Cheng, E. Gjika, L. Lin, J. Canady, J. Sherman, C. Young, and M. Keidar.Cold atmospheric plasma (CAP) treatment is a rapidly expanding and emerging technology for cancer treatment. Direct CAP jet irradiation is limited to the skin and it can...
Enhancing Cold Atmospheric Plasma Treatment of Cancer Cells by Static Magnetic Field
Xiaoqian Cheng, Kenan Rajjoub, Alexey Shashurin, Dayun Yan, Jonathan H. Sherman, Ka Bian, Ferid Murad, and Michael KeidarIt has been reported since late 1970 that magnetic field interacts strongly with biological systems. Cold atmospheric plasma (CAP) has also been...
Differential effects of cold atmospheric plasma in the treatment of malignant glioma
Siu, A., Volotskova, O., Cheng, X., Khalsa, S. S., Bian, K., Murad, F., & Sherman, J. H.Cold atmospheric plasma (CAP) is a partially ionized gas that can focally deliver low levels of ultraviolet (UV) radiation and ionized particles to synergistically generate...
Anti-Cancer Therapies of 21st Century: Novel Approach to Treat Human Cancers Using Cold Atmospheric Plasma
Edward A. Ratovitski, Xiaoqian Cheng, Dayun Yan, Barry Trink, PhD, Jonathan H. Sherman, Jerome Canady, MD, Michael KeidarCold atmospheric plasma (CAP) has just recently been showing promising anti-cancer activities supported by ability to induce cell death via...
The Effect of Tuning Cold Plasma Composition on Glioblastoma Cell Viability
Xiaoqian Cheng, Jonathan Sherman, William Murphy, Edward Ratovitski, Jerome Canady, MD, Michael KeidarRecent development in physics research has lead to the production of cold atmospheric pressure plasma, a type of plasma that is formed at relatively “cold”...
Synergistic Effect of Gold Nanoparticles and Cold Plasma on Glioblastoma Cancer Therapy
Xiaoqian Cheng, William Murphy, Nina Recek, Dayun Yan, Uros Cvelbar, Alenka Vesel, Miran Mozetič, Jerome Canady, MD, Michael Keidar, PhD, Jonathan H ShermanGold nanoparticles (AuNPs) have been investigated as a promising reagent for cancer therapy in various fields....
Cold Atmospheric Plasma for Selectively Ablating Metastatic Breast Cancer Cells
Mian Wang, Benjamin Holmes, Xiaoqian Cheng, Wei Zhu, Michael Keidar, PhD, Lijie Grace ZhangBreast cancer is the second leading cause of cancer deaths in women. It is estimated that 232,340 new cases of invasive breast cancer will be diagnosed in the United States and...
Cold Atmospheric Plasma in Cancer Therapy
Michael Keidar, PhD, Alexey Shashurin, PhD, Olga Volotskova, Mary Ann Stepp, Priya Srinivasan et alRecent progress in atmospheric plasmas has led to the creation of cold plasmas with ion temperature close to room temperature. This paper outlines recent progress in...
E Posters from The 2022 International Biennial Conference of The Israel Society of Surgical Oncology
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The Granger-Causal Effects of Canady Helios Cold Plasma on the Inhibition of Breast Cancer Cell Proliferation
The Canady Helios Cold Atmospheric Plasma in Combination with Senescence Inducing Drug CPI203 Regimen for the Treatment of Drug Resistance Cancers
Canady Helios Cold Plasma Dosimetry to Treat Solid Tumors
Canady Helios Cold Plasma Reduces Soft Tissue Sarcoma Cell Viability by Inducing Apoptosis and Differential Gene Regulation
OTHER PUBLICATIONS
Comprehensive Clinical Plasma Medicine
Hans-Robert Metelmann, Thomas von Woedtke, and Klaus-Dieter WeltmannColorectal cancer (CRC) is the third most common cancer in the world and the second leading cause of cancer death in the United States. In 2012 an estimated 103,170 new cases of colon cancer and...
Selective treatment of pancreatic cancer cells by plasma-activated saline solutions
Zhitong Chen, Li Lin, Eda Gjika, Xiaoqian Cheng, Jerome Canady, Michael KeidarSELF-ORGANIZATION is generally referred to as a process of spontaneous transition from a homogeneous stable state to a regular pattern in a spatially extended system [1], [2]....
The cutting mechanism of the electrosurgical scalpel
E. Gjika, M. Pekker, A. Shashurin, M. Shneider, T. Zhuang, J. Canady, and M. KeidarElectrosurgical cutting is a well-known technique for creating incisions often used for the removal of benign and malignant tumors. The proposed mathematical model suggests that...
Treatment of gastric cancer cells with nonthermal atmospheric plasma generated in water
Z. Chen, L. Lin, X. Chen, E. Gjika, and M. KeidarGastric cancer is one of the most aggressive types of carcinomas and it is known as the second most common cause of death. Worldwide, the number of newly diagnosed cases is predicted to reach 930,000 per year. Although...
Efficacy of Hybrid Plasma Scalpel in Reducing Blood Loss and Transfusions in Direct Anterior Total Hip Arthroplasty
George N. Guild, III, MD1, Robert P. Runner, MD, Gina M. Castilleja, RN, Melissa J. Smith, MS, ATC, Cat Phuong L. Vu, BAAllogeneic blood transfusions have inherent risk and direct cost in total hip arthroplasty. Anterior total hip arthroplasty has grown in popularity...
Electric Discharge During Electrosurgery
A. Shashurin, D. Scott, T. Zhuang, J. Canady, I. Beilis, M. KeidarElectric discharge utilized for electrosurgery is studied by means of a recently developed method for the diagnostics of small-size atmospheric plasma objects based on Rayleigh scattering of microwaves...
Temporal Evolution of the Discharge in U.S. Medical Innovations Electrosurgical System SS-200E/Argon-2
Scott, D.; Shashurin, A.; Canady, J.; Keidar, M.A series of instant photographs of a discharge produced by the electrosurgical system SS-200E/Argon-2 by U.S. Medical Innovations is presented and analyzed.
Controlling Plasma Stimulated Media in Cancer Treatment Application
Dayun Yan, Jonathan H. Sherman, Xiaoqian Cheng, Edward Ratovitski, Jerome Canady, MD, Michael Keidar, PhDCold atmospheric plasma (CAP) constitutes a “cocktail” of various reactive species. Accumulating evidence shows the effectiveness of CAP in killing cancer cells...
Characterization of Plasma Parameters and Tissue Injury Produced by Plasma Electrosurgical Systems
Jerome Canady, MD, Alexey Shashurin, PhD, Kimberley Wiley, MD, N. J. Fisch, Michael Keidar, PhDy Plasma Electrosurgical SystemsApplication of plasma in medicine has a long history and it primarily relies on the thermal effects of plasma. In this respect, heat and high...
Circular periodic motion of plasma produced by a small-scale vacuum arc
T. Zhuang, A. Shashurin, M. Keidar, I. BelisA small-scale plasma source based on a low-current vacuum arc is described. Temporal and spatial evolution of the ion current is measured. The plasma plume circular motion follows the cathode spot motion in the retrograde...
Arc plasma synthesis of carbon nanostructures: where is the frontier?
M. Keidar, A. Shashurin, J. Li, O. Volotskova, M. Kundrapu, T. ZhuangIn this perspective paper, we critically analyse the state-of-the-art of arc discharge technique of carbon nanoparticle synthesis. We discuss improving controllability of the arc discharge synthesis...
Application of electrostatic Langmuir probe to atmospheric arc plasmas producing nanostructures
A. Shashurin, J. Li, T. Zhuang, M. Keidar, I. BelisThe temporal evolution of a high pressure He arc producing nanotubes was considered and the Langmuir probe technique was applied for plasma parameter measurements. Two modes of arc were observed: cathodic arc where...
Argon Plasma Coagulation and the Future Applications for Dual-Mode Endoscopic Probes
Jerome Canady, MD, Kimberly Wiley, MD, Biagio Ravo, MDArgon plasma coagulation (APC) is a thermoablative technique increasingly being used in endoscopy. Since its introduction, the flexible APC probe has been employed by endoscopists throughout the world. APC has...